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SILVERLINING℠ continues to be the cutting edge provider when it comes to the advancements in modern psychiatry. 

Understanding Spravato (Esketamine):

A New Hope for Treatment-Resistant Depression

Depression is a common but serious mood disorder that affects many people around the world. For some, traditional antidepressants and therapies may not be effective, leading to a condition known as treatment-resistant depression. However, a new medication called Spravato (Esketamine) offers a ray of hope for those struggling with this challenging condition.


What is Spravato (Esketamine)?

Spravato is an FDA-approved nasal spray that contains esketamine, a rapid-acting and powerful antidepressant. It is specifically designed for adults with treatment-resistant depression or acute suicidality who have not responded adequately to at least two different antidepressants.


How Does Spravato Work?

Esketamine works differently from traditional antidepressants. It targets the NMDA receptors in the brain, which are involved in mood regulation and cognitive functions. By modulating these receptors, Spravato can provide rapid relief from depressive symptoms.


The Treatment Protocol

The typical treatment protocol for Spravato involves an initial induction phase of twice-weekly sessions for four weeks, followed by a maintenance phase with sessions every two to four weeks. In most cases, the treatment is completed in 14 sessions over 90 days. During treatment, patients must be monitored for at least two hours after administration due to the potential for side effects such as dizziness, nausea, and increased blood pressure. We provide every patient with a private room equipped with a sofa, blankets and pillows, a call button and an easy access to the restroom.  

Patient Experiences

Patients who have undergone Spravato treatment report a range of experiences. Some describe enhanced empathy and relaxation, while others note feelings of dissociation during the sessions. Over time, many find their sessions to become more relaxing and pleasant as they adjust to the medication.


Insurance Coverage

Spravato is covered by major insurance plans through the prior authorization process with the nominal copayment. Our staff will keep you informed on the details of your pre-approval with insurance as well as your individual cost.



Spravato represents a significant advancement in the treatment of depression. By offering a new mechanism of action and a rapid onset of effects, it provides hope for those who have not found relief through other treatments. As with any medication, it’s essential to consult with the knowledgeable healthcare provider to determine if Spravato is the right option for you. It is extremely unsafe to use any form of ketamine at home without the medical supervision.


I hope this newsletter gives you a good overview of Spravato and its potential benefits for those with treatment-resistant depression. 

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